I use all optimized BIOS settings (OoB, no OC yet) despite a few changes listed in detail below:

1.) /AI Tweaker/
a.) ASUS MultiCore Enhancement: Disabled/Enabled [see important notification below!]​
b.) CPU Core Ratio: Sync All Cores​
c.) DRAM Frequency: DDR4-3200MHz​
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2.) /AI Tweaker/Internal CPU Power Management/
a.) Enhanced Intel Speed Step Technology: Disabled​
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3.) /Advanced/CPU Configuration/
a.) Hyper Threading [ALL]: Enabled​
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4.) /Advanced/CPU Configuration/CPU Power Management Configuration/
a.) Enhanced Intel Speed Step Technology: Disabled​
b.) Autonomous Core C-States: Enabled​
c.) Enhanced Halt State (C1E): Enabled​
d.) CPU C6 report: Enabled​
e.) Package C-State: C6(non retention) state​
f.) MFC Mode Override: OS Native​
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5.) /Advanced/System Agent Configuration/
a.) Intel VT for Directed I/O (VT-d): Disabled​

6.) /Advanced/PCH Storage Configuration/PCI Subsystem Settings/
a.) Above 4G Decoding: Enabled
b.) Re-Sitze BAR Support: Disable

7.) /Boot/
a.) Fast Boot: Disabled​
b.) Above 4G Decoding: On​
c.) Set your specific Boot Option Priorities​
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8.) /Boot/Boot Configuration
a.) Boot Logo Display: Full Screen​
b.) Boot up NumLock State: Disabled​
c.) Setup Mode: Advanced​
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9.) /Boot/Compatibility Support Module/
a.) Launch CSM: Disabled​

10.) /Boot/Secure Boot/
a.) OS Type: Other OS​
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With F7 and F10 you can save the modified BIOS settings.